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Primary Adrenal Insufficiency : A Case Study & Review of Literature
Autoimmune Addison disease affects the function of the adrenal glands, which are small hormone-producing glands located on top of each kidney. It is classified as an autoimmune disorder because it results from a malfunctioning immune system that attacks the adrenal glands. As a result, the production of several hormones is disrupted, which affects many body systems. The signs and symptoms of autoimmune Addison disease can begin at any time, although they most commonly begin between ages 30 and 50. Common features of this condition include extreme tiredness (fatigue), nausea, decreased appetite, and weight loss. In addition, many affected individuals have low blood pressure (hypotension), which can lead to dizziness when standing up quickly; muscle cramps; and a craving for salty foods. A characteristic feature of autoimmune Addison disease is abnormally dark areas of skin (hyperpigmentation), especially in regions that experience a lot of friction, such as the armpits, elbows, knuckles, and palm creases. The lips and the inside lining of the mouth can also be unusually dark. Because of an imbalance of hormones involved in development of sexual characteristics, women with this condition may lose their underarm and pubic hair.
About the Speaker
Dr. Sandip Ghosh
Consultant Endocrinologist, Zulekha Hospitals, Sharjah, UAE
Upcoming Case Discussions
Pediatric and Adult Veneers: Case Studies
Pediatric dental veneers can be transformative in restoring smiles and dental function in children with various dental issues. Case studies illustrate the efficacy and benefits of veneers in pediatric dentistry. They might showcase how veneers can improve the appearance of discolored or malformed teeth, enhancing a child's self-esteem. They might also demonstrate how veneers can correct dental imperfections caused by injury or developmental abnormalities. These studies highlight the importance of personalized treatment plans tailored to each child's unique dental needs. Veneers in pediatric dentistry offer durable and aesthetic solutions, often with minimal tooth preparation, making them suitable for young patients. Through case studies, dental professionals can showcase successful outcomes and educate parents about the potential advantages of veneers in enhancing their child's dental health and confidence.
H. pylori Treatment with PYELRA®: Best Practices
PYLERA® is a medication used for the treatment of Helicobacter pylori (H. pylori) infection, a common cause of stomach ulcers and gastritis. It contains a combination of three active ingredients: bismuth subcitrate potassium, metronidazole, and tetracycline. This combination works synergistically to eradicate H. pylori bacteria and reduce associated symptoms. Treatment with PYLERA® typically involves taking multiple capsules four times a day for a specified duration, as prescribed by a healthcare provider. It is important to follow the treatment regimen as directed and to discuss potential side effects
Osteoporosis: Basic Facts
Postpartum hemorrhage (PPH) is a significant complication following childbirth, characterized by excessive bleeding within 24 hours of delivery. It's a leading cause of maternal mortality globally. PPH can occur due to various factors, including uterine atony (failure of the uterus to contract), trauma during childbirth, retained placental tissue, or coagulation disorders. Prompt recognition and intervention are crucial to prevent severe consequences. Management typically involve uterine massage, administration of uterotonic medications, uterine artery embolization, or, in severe cases, surgical interventions like hysterectomy. Timely and effective management strategies are essential to reduce maternal morbidity and mortality associated with PPH. Osteoporosis is a progressive bone disease characterized by decreased bone density and structural deterioration, leading to an increased risk of fractures, particularly in the spine, hips, and wrists. It often develops silently over years, with no symptoms until a fracture occurs. Factors such as aging, hormonal changes, inadequate nutrition (especially calcium and vitamin D deficiency), sedentary lifestyle, and certain medications contribute to its development. Prevention and management strategies include weight-bearing exercises, adequate calcium and vitamin D intake, lifestyle modifications to reduce risk factors, and sometimes medication to strengthen bones and reduce fracture risk. Early detection through bone density testing and proactive intervention are crucial in mitigating its impact on individuals' health and quality of life.
Amenorrhea: Clinical Features & Treatment
Amenorrhea refers to the absence of menstrual periods in women of reproductive age and can be classified as either primary or secondary. Clinical features of amenorrhea may include hot flashes, vaginal dryness, breast changes, headaches, and hair loss, depending on the underlying cause such as hormonal imbalances, stress, or anatomical abnormalities. Diagnosis involves a thorough medical history, physical examination, and tests including hormone levels (e.g., FSH, LH, estradiol, thyroid function tests) and imaging studies (e.g., ultrasound, MRI). Treatment depends on the cause and may include lifestyle modifications, hormone replacement therapy, medications to induce ovulation, or surgical intervention in cases of structural abnormalities. Management aims to address underlying factors, restore menstrual function, and address any associated symptoms or complications of amenorrhea. Regular follow-up and monitoring are essential to assess treatment efficacy and address any new concerns or changes in symptoms.
Science Behind Resuscitation
Resuscitation is a critical medical intervention aimed at restoring spontaneous circulation and breathing in individuals experiencing cardiac arrest or respiratory failure. The science behind resuscitation involves a multifaceted approach, including prompt recognition of the emergency, initiation of cardiopulmonary resuscitation (CPR) to maintain blood circulation and oxygenation, defibrillation to correct life-threatening cardiac arrhythmias, and advanced life support interventions such as airway management and medication administration. Key principles underlying successful resuscitation include early access to care, high-quality CPR, effective teamwork and communication among healthcare providers, and timely integration of advanced interventions based on the latest evidence-based guidelines. The ultimate goal of resuscitation is to improve the chances of survival with good neurological outcomes for patients in cardiac or respiratory arrest.