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HMOs and gut development: A latest clinical Update
The effects of Human Milk Oligosaccharides (HMOs) on the infant gut are profound, influencing gut microbiome development and health trajectories through toddlerhood. Various HMOs, their doses, and periods of supplementation have been investigated, with clinical evidence supporting the supplementation of five key HMOs. HMOs are now incorporated into infant formula to mimic the benefits of breast milk, while non-human oligosaccharides are also explored for their potential benefits. Safety profiles and regulatory considerations are critical in the use of HMOs, which has advanced through improved synthesis and production techniques for clinical application. Real-world examples and case studies demonstrate the benefits of HMOs, and ongoing research is uncovering new possibilities for their application in promoting infant gut health.
About the Speaker
Dr. Sunil Kumar Sehgal
Consultant Pediatrician, Safdarjung Enclave, Delhi
Dr Sunil Kumar Sehgal, a distinguished pediatrician in Safdarjung Enclave, Delhi, brings 44 years of rich experience to his practice at Dr Sehgal’s Clinic. He completed his MBBS from Maulana Azad Medical College, New Delhi, in 1980, followed by a Diploma in Child Health (DCH) in 1983 from the same institution. Dr Sehgal furthered his education with an MD in pediatrics from Safdarjung Hospital, University of Delhi, in 1985. His extensive training and expertise underscore his commitment to providing high-quality care for children and families in the community.
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Upcoming Case Discussions
Clinician’s Approach to Hypertensive Nephropathy
Many processes influence the management of chronic kidney disease (CKD) and lead to the development of hypertension in the disease. Increased sympathetic tone in patients with chronic kidney disease (CKD) is a result of afferent signals produced by functionally failing kidneys. The great majority of CKD patients suffer from hypertension, which can both cause and result from the disease. In people with CKD, controlling hypertension is crucial since it lowers the risk of CVD and slows the disease's course. There is no agreement on the ideal blood pressure (BP) targets provided by current guidelines. Consequently, when deciding how to care specific patients.
Anaphylaxis In Emergency Department
A dangerous systemic hypersensitivity reaction with a typically quick onset that can be fatal is anaphylaxis. Rapid onset of breathing, circulation,and/or airway issues are its defining characteristics. The most crucial treatment is intramuscular adrenaline, although many patients do not receive it even in medical facilities, despite recommendations to the contrary. The significance of positioning during the management of anaphylaxis and the necessity of avoiding activities that could postpone the timely and proper delivery of adrenaline. Antihistamines should only be used as a last resort when ABC characteristics have been successfully treated in order to lessen skin involvement.
Circulatory Shock In Trauma
The inability of the circulatory system to supply tissue oxygenation and organ perfusion necessary to meet cellular metabolic demands is known as shock. Although non-haemorrhagic shock, such as cardiogenic or neurogenic shock, can occur after trauma, hemorrhage is more frequently linked to trauma-related shock. Evidence gathered over the past ten years has shown that trauma patients suffer from acute traumatic coagulopathy (ATC), which is brought on by the actual process of injury. Damage control resuscitation (DCR), the current method for managing acute shock, was developed with this as a key component. Haemostatic resuscitation, which uses blood products as the main resuscitative fluid, permissive hypotension, and damage control surgery are the three main resuscitative techniques included in DCR.
Fertilization & Early Development
Fertilization occurs when a sperm cell merges with an egg cell, creating a zygote, which is the first stage of a new life. This process takes place in the fallopian tube. The zygote then undergoes rapid cell division, known as cleavage, forming a multi-cellular structure called a blastocyst. As the blastocyst moves toward the uterus, it continues to divide and develop. Approximately 5-7 days after fertilization, the blastocyst implants itself into the uterine lining, initiating pregnancy. Early development involves the formation of the foundational structures and systems that will shape the embryo.
Metabolic Syndrome and Heart Health
Metabolic syndrome is a cluster of conditions that increase the risk of heart disease, stroke, and type 2 diabetes. These conditions include high blood pressure, elevated blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels. When these risk factors occur together, they amplify the risk of developing cardiovascular issues. Metabolic syndrome is closely linked to insulin resistance, where the body struggles to use insulin effectively. Lifestyle changes, such as adopting a healthy diet, regular exercise, and weight management, are crucial in managing the syndrome. Early intervention is essential to prevent the progression to heart disease and other complications.
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Dr. Sunil Kumar Sehgal's Talks on Assimilate
- 17th-July-2024, TIME : 4:00PM TO 5:00 PM
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The effects of Human Milk Oligosaccharides (HMOs) on the infant gut are profound, influencing gut microbiome development and health trajectories through toddlerhood. Various HMOs, their doses, and periods of supplementation have been investigated, with clinical evidence supporting the supplementation of five key HMOs. HMOs are now incorporated into infant formula to mimic the benefits of breast milk, while non-human oligosaccharides are also explored for their potential benefits. Safety profiles and regulatory considerations are critical in the use of HMOs, which has advanced through improved synthesis and production techniques for clinical application. Real-world examples and case studies demonstrate the benefits of HMOs, and ongoing research is uncovering new possibilities for their application in promoting infant gut health.