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Misunderstood Coagulopathy in Liver Diseases

An indicator of the clinical efficacy of vitamin-K antagonist therapy is the international normalized ratio (INR). Nonetheless, it is frequently employed in the acute context to evaluate the level of coagulopathy in individuals suffering from acute liver failure or hepatic cirrhosis. This frequently affects therapeutic choices regarding invasive operations or the necessity of potentially hazardous and needless blood product transfusions. This might not be an evidence-based or best-practice method of patient care. Using a number of scholarly search engines, the author conducted a study of the literature regarding the usefulness of INR in cirrhosis patients. The literature contradicts the widely held belief that a cirrhotic patient's elevated INR during invasive operations translates into a higher risk of hemorrhagic events.

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Dr. Rohit Mehtani Profile Image

Dr. Rohit Mehtani

Assistant Professor, Amrita Hospital, Faridabad

Dr. Rohit Mehtani, Assistant Professor, Amrita Hospital, Faridabad

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An indicator of the clinical efficacy of vitamin-K antagonist therapy is the international normalized ratio (INR). Nonetheless, it is frequently employed in the acute context to evaluate the level of coagulopathy in individuals suffering from acute liver failure or hepatic cirrhosis. This frequently affects therapeutic choices regarding invasive operations or the necessity of potentially hazardous and needless blood product transfusions. This might not be an evidence-based or best-practice method of patient care. Using a number of scholarly search engines, the author conducted a study of the literature regarding the usefulness of INR in cirrhosis patients. The literature contradicts the widely held belief that a cirrhotic patient's elevated INR during invasive operations translates into a higher risk of hemorrhagic events.