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Intrahepatic Cholestasis in Pregnancy: An Overview and Update
Intrahepatic Cholestasis of Pregnancy (ICP) is a liver disorder that specifically occurs during pregnancy, typically in the third trimester. It is characterized by impaired bile flow within the liver, leading to the accumulation of bile acids in the bloodstream. While the exact cause is not fully understood, hormonal changes during pregnancy, genetic factors, and environmental influences may contribute to the development of ICP. Symptoms of ICP include intense itching, particularly on the hands and feet, which is often more pronounced at night. Other symptoms may include dark urine, pale stools, and jaundice. ICP poses potential risks to both the mother and the fetus. Increased levels of bile acids in the maternal bloodstream can be associated with adverse pregnancy outcomes, such as preterm birth, fetal distress, and stillbirth. Therefore, early detection and appropriate management are crucial.
About the Speaker
Dr. Krishi Gowdra
Specialist Obstetrics & Gynecology, Zulekha Hospital
Upcoming Case Discussions
New Approach of treatment of Diabetic Neuropathy
Emerging treatments for diabetic neuropathy focus on addressing the root causes and providing symptomatic relief. Novel therapies include advanced pain management drugs, nerve regeneration techniques, and the use of antioxidants like alpha-lipoic acid. Regenerative medicine approaches, such as stem cell therapy, aim to repair damaged nerves. Personalized treatment plans incorporating lifestyle changes, glycemic control, and physical therapy are gaining importance. These innovative strategies improve quality of life and target long-term nerve health in diabetic patients.
Alpha Lipoic Acid in Oxidative Stress
Alpha-lipoic acid (ALA) is a potent antioxidant that helps combat oxidative stress by neutralizing free radicals. It regenerates other antioxidants like vitamin C and E, enhancing overall antioxidant defense. ALA plays a crucial role in reducing cellular damage caused by conditions like diabetes, neuropathy, and aging. Its ability to function in both water- and fat-soluble environments makes it versatile in protecting various tissues. Regular supplementation of ALA may improve mitochondrial function and reduce inflammation associated with oxidative stress.
Evaluating Cardiac Function in Sepsis and Septic Shock
Cardiac dysfunction is common in sepsis and septic shock, requiring careful evaluation for optimal management. Echocardiography is the cornerstone for assessing myocardial function, including ejection fraction and cardiac output. It detects ventricular dilation, reduced contractility, or other abnormalities. Biomarkers like troponins and B-type natriuretic peptide (BNP) help identify myocardial injury and stress. Hemodynamic monitoring, using tools like pulmonary artery catheters or pulse contour analysis, provides insights into cardiac output and systemic vascular resistance. Early identification of cardiac dysfunction enables tailored interventions.
Clinician’s Approach to Acute Respiratory Distress Syndrome
A clinician’s approach to respiratory infections involves a thorough assessment of symptoms, patient history, and risk factors, followed by diagnostic testing such as sputum cultures, chest X-rays, or PCR tests to identify the causative pathogen. Based on the diagnosis, appropriate antimicrobial therapy, supportive care, and close monitoring for complications are initiated, with attention to managing comorbid conditions and preventing the spread of infection.
Cancer and Air Pollution: The Delhi Dilemma
Cancer and air pollution are deeply intertwined in Delhi, where pollution levels rank among the highest globally. Prolonged exposure to particulate matter and carcinogenic toxins in the air increases the risk of respiratory and lung cancers. The city's residents face a significant health burden, particularly vulnerable groups like children and the elderly. Addressing this challenge requires stringent pollution control measures, public health awareness, and policy interventions. The Delhi dilemma underscores the urgent need for sustainable urban planning and environmental regulations to protect public health.
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