Hypertension: mechanism and approach to target organ protection

Hypertension is a common condition characterized by abnormally high blood pressure levels. The mechanism underlying hypertension involves an increase in peripheral vascular resistance and/or an increase in cardiac output. Several factors can contribute to the development of hypertension, including age, family history, obesity, physical inactivity, and smoking. Hypertension can cause damage to target organs such as the heart, kidneys, and brain, leading to cardiovascular disease, renal failure, and stroke. Effective management of hypertension involves targeting the underlying mechanism and implementing measures to protect target organs from damage. The mainstay of hypertension management is lifestyle modifications, including weight loss, regular physical activity, and a healthy diet. In addition to lifestyle modifications, pharmacological interventions are also used to manage hypertension. Antihypertensive medications can be classified based on their mechanism of action, including diuretics, beta-blockers, calcium channel blockers, and angiotensin-converting enzyme (ACE) inhibitors.

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Dr.Ramkumar Sundaraperumal 
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Dr.Ramkumar Sundaraperumal

HOD and Specialist Internal Medicine, Zulekha hospital, Dubai

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