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Dapagliflozin in patients with Chronic Kidney Disease
Dapagliflozin is a sodium-glucose cotransporter-2 (SGLT-2) inhibitor that has shown promise in the management of Chronic Kidney Disease (CKD) in patients with type 2 diabetes. Dapagliflozin has demonstrated efficacy in reducing the progression of CKD in individuals with type 2 diabetes by inhibiting the reabsorption of glucose and sodium in the proximal renal tubules. Clinical trials have indicated that dapagliflozin reduces albuminuria, a key marker of kidney damage, thereby potentially slowing the decline in renal function. The use of dapagliflozin has been associated with improvements in glomerular filtration rate (GFR), suggesting a positive impact on overall kidney function. Dapagliflozin's mechanism of action involves promoting glycosuria and natriuresis, leading to a reduction in intraglomerular pressure and ultimately protecting the kidneys. Studies have highlighted the cardiovascular benefits of dapagliflozin in CKD patients, including a reduction in major adverse cardiovascular events and heart failure hospitalizations. Dapagliflozin's renal protective effects extend beyond glycemic control, making it a valuable therapeutic option for patients with both diabetes and CKD. The safety profile of dapagliflozin in CKD patients appears favorable, with few adverse effects reported in clinical trials. Dapagliflozin's impact on renal outcomes has prompted its inclusion in treatment guidelines for individuals with type 2 diabetes and CKD.
About the Speaker
Dr Satyanarayana Garre
Consultant Nephrologist, Apollo Hospitals, Hyderabad
Upcoming Case Discussions
Acne: Disorders and Treatment Approaches
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Gallstone Disease & Cholecystitis: When to Operate?
iGallstone disease and cholecystitis are common conditions requiring careful evaluation to determine the need for surgery. Symptomatic gallstones causing recurrent pain, nausea, or complications like cholecystitis often necessitate cholecystectomy. Acute cholecystitis, characterized by inflammation, fever, and right upper quadrant pain, typically requires early surgical intervention to prevent complications like perforation or sepsis. In high-risk patients, conservative management with antibiotics and drainage may be considered. Elective surgery is recommended for asymptomatic patients with high-risk factors, such as large gallstones or gallbladder polyps, to prevent future complications.
