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Clinician’s Approach to Opioid Free Anesthesia
Opioids have long been used in general anesthesia to effectively manage pain. However, data suggests that using opioids during surgery may result in postoperative hyperalgesia, which can lead to chronic postsurgical pain (CPSP) and long-term opioid dependence. Indeed, opioid abuse has become a worldwide concern, with an estimated 40.5 million opioid dependent persons in 2017. Opioid-free anesthesia may thus be an appropriate option. A short time of opioid exposure has been demonstrated to cause epigenetic alterations and a pro-inflammatory state, resulting in nociceptive hypersensitivity. Opioids provided during tissue injury (e.g., surgery) may cause a paradoxical increase in acute postoperative pain and opioid-induced hyperalgesia (OIH), both of which contribute to the development of CPSP.
About the Speaker
Dr. Namita Sharma
Head of the Department Anesthesiology and Pain Management, Aakash Healthcare, Delhi
Dr. Namita Sharma, Head of the Department Anesthesiology and Pain Management, Aakash Healthcare, Delhi
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Dr. Namita Sharma's Talks on Assimilate
- 15th -Oct -2024, TIME : 5:00PM TO 6:00 PM
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Opioids have long been used in general anesthesia to effectively manage pain. However, data suggests that using opioids during surgery may result in postoperative hyperalgesia, which can lead to chronic postsurgical pain (CPSP) and long-term opioid dependence. Indeed, opioid abuse has become a worldwide concern, with an estimated 40.5 million opioid dependent persons in 2017. Opioid-free anesthesia may thus be an appropriate option. A short time of opioid exposure has been demonstrated to cause epigenetic alterations and a pro-inflammatory state, resulting in nociceptive hypersensitivity. Opioids provided during tissue injury (e.g., surgery) may cause a paradoxical increase in acute postoperative pain and opioid-induced hyperalgesia (OIH), both of which contribute to the development of CPSP.