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Novel Biomarkers in Sepsis
Elevated levels of PCT serve as a valuable biomarker in sepsis, aiding in the early diagnosis and monitoring of bacterial infections, and guiding therapeutic decisions. CRP is a commonly used biomarker for inflammation, and its levels are frequently elevated in sepsis, providing clinicians with an indication of the severity of the immune response. Elevated lactate levels are associated with tissue hypoxia and serve as a crucial biomarker in sepsis, aiding in the assessment of organ dysfunction and prognosis. Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1): Elevated sTREM-1 levels are indicative of bacterial infections, making it a promising biomarker for identifying sepsis of infectious origin. Endothelial Biomarkers (E-selectin, VCAM-1): Increased expression of endothelial biomarkers reflects endothelial dysfunction in sepsis, contributing to the understanding of the pathophysiology and progression of the condition.
About the Speaker
Dr. Adel Mohamed Yasin Al Sisi
Critical care Specialist,Prime Hospitals, Dubai
He has his expertise in critical care and emergency medicine with over 16 years of experience in dealing with acutely ill patients. Additionally he is an international reviewer of ICU articles and Participated as an author in ICU textbooks. He has in interest in Endotracheal and Nasotracheal intubation, use of mechanical ventilation , Insertion of Central Venous and Arterial access , Tapping of pleural effusion- Paracentesis , Pericardiocentesis , use of DC electrical shocks either in Advanced Cardiac Life Support or in the management of tachyarrhythmias.
Upcoming Case Discussions
New Approach of treatment of Diabetic Neuropathy
Emerging treatments for diabetic neuropathy focus on addressing the root causes and providing symptomatic relief. Novel therapies include advanced pain management drugs, nerve regeneration techniques, and the use of antioxidants like alpha-lipoic acid. Regenerative medicine approaches, such as stem cell therapy, aim to repair damaged nerves. Personalized treatment plans incorporating lifestyle changes, glycemic control, and physical therapy are gaining importance. These innovative strategies improve quality of life and target long-term nerve health in diabetic patients.
Alpha Lipoic Acid in Oxidative Stress
Alpha-lipoic acid (ALA) is a potent antioxidant that helps combat oxidative stress by neutralizing free radicals. It regenerates other antioxidants like vitamin C and E, enhancing overall antioxidant defense. ALA plays a crucial role in reducing cellular damage caused by conditions like diabetes, neuropathy, and aging. Its ability to function in both water- and fat-soluble environments makes it versatile in protecting various tissues. Regular supplementation of ALA may improve mitochondrial function and reduce inflammation associated with oxidative stress.
Evaluating Cardiac Function in Sepsis and Septic Shock
Cardiac dysfunction is common in sepsis and septic shock, requiring careful evaluation for optimal management. Echocardiography is the cornerstone for assessing myocardial function, including ejection fraction and cardiac output. It detects ventricular dilation, reduced contractility, or other abnormalities. Biomarkers like troponins and B-type natriuretic peptide (BNP) help identify myocardial injury and stress. Hemodynamic monitoring, using tools like pulmonary artery catheters or pulse contour analysis, provides insights into cardiac output and systemic vascular resistance. Early identification of cardiac dysfunction enables tailored interventions.
Clinician’s Approach to Acute Respiratory Distress Syndrome
A clinician’s approach to respiratory infections involves a thorough assessment of symptoms, patient history, and risk factors, followed by diagnostic testing such as sputum cultures, chest X-rays, or PCR tests to identify the causative pathogen. Based on the diagnosis, appropriate antimicrobial therapy, supportive care, and close monitoring for complications are initiated, with attention to managing comorbid conditions and preventing the spread of infection.
Cancer and Air Pollution: The Delhi Dilemma
Cancer and air pollution are deeply intertwined in Delhi, where pollution levels rank among the highest globally. Prolonged exposure to particulate matter and carcinogenic toxins in the air increases the risk of respiratory and lung cancers. The city's residents face a significant health burden, particularly vulnerable groups like children and the elderly. Addressing this challenge requires stringent pollution control measures, public health awareness, and policy interventions. The Delhi dilemma underscores the urgent need for sustainable urban planning and environmental regulations to protect public health.
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Dr. Adel Mohamed Yasin Al Sisi 's Talks on Assimilate
- 21st-December-2023, TIME : 03:00PM - 04:00PM
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Elevated levels of PCT serve as a valuable biomarker in sepsis, aiding in the early diagnosis and monitoring of bacterial infections, and guiding therapeutic decisions. CRP is a commonly used biomarker for inflammation, and its levels are frequently elevated in sepsis, providing clinicians with an indication of the severity of the immune response. Elevated lactate levels are associated with tissue hypoxia and serve as a crucial biomarker in sepsis, aiding in the assessment of organ dysfunction and prognosis. Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1): Elevated sTREM-1 levels are indicative of bacterial infections, making it a promising biomarker for identifying sepsis of infectious origin. Endothelial Biomarkers (E-selectin, VCAM-1): Increased expression of endothelial biomarkers reflects endothelial dysfunction in sepsis, contributing to the understanding of the pathophysiology and progression of the condition.