Pyrexia of Unknown Origin (PUO) remains one of the most intriguing and diagnostically challenging clinical presentations in internal medicine. This session offers a comprehensive, case-based exploration of PUO, guiding learners through a systematic, evidence-based approach to diagnosis. Participants will engage with real-world clinical cases that highlight the complexity and nuances of prolonged fever without an identifiable source.
The session will cover the evolving definitions of PUO, classification into major subtypes (classic, nosocomial, neutropenic, and HIV-associated), and a structured roadmap for investigations—including clinical history-taking, physical examination pearls, essential lab workups, and the judicious use of imaging and invasive diagnostics. Emphasis will be placed on narrowing differentials using organ system-based thinking, understanding red flag indicators, and recognizing when to reconsider diagnoses or stop investigations.
Through practical case discussions, attendees will gain deeper insights into common and rare causes of PUO—from infections and malignancies to autoimmune disorders and drug fevers. The session is designed to strengthen diagnostic reasoning and reduce cognitive bias in evaluating febrile patients.
Consultant Physician, Medicover Hospitals, Andhra Pradesh
Dr. Meghanath Yenni, a seasoned Consultant Physician with over a decade of clinical experience in General Internal Medicine. He currently practices at Medicover Hospitals, one of India’s leading multi-specialty hospital chains, and also runs his independent OP clinic, First Choice Clinics in Visakhapatnam—an integrated care center offering outpatient consultations, lab services, and a full-service pharmacy. Dr. Yenni’s clinical acumen spans the management of a wide range of acute and chronic conditions, grounded in precision-based care and compassionate communication. He holds a PG Diploma in Infectious Diseases from the University of New South Wales (UNSW) and a Postgraduate Program in Rheumatology from Johns Hopkins University, reflecting his academic commitment to continual learning. His frontline contributions during the COVID-19 pandemic underscore both his resilience and dedication to patient care. Beyond his medical practice, Dr. Yenni is a multifaceted professional—a writer, poet, and educator—who believes in simplifying complex clinical ideas through creative formats. Whether it’s through AI-powered learning tools, patient education content, or poetic healthcare narratives, he crafts impactful messages that resonate with both professionals and the public. A passionate advocate for digital health transformation, Dr. Yenni actively explores the role of AI, wearable tech, and digital tools in enhancing clinical decision-making and personalized care. He also champions Medico-legal literacy among practitioners, emphasizing its importance in safeguarding both doctors and patients. Collaborative at heart, innovative in spirit, and deeply humanistic in approach, Dr. Yenni exemplifies the modern physician-scholar, blending medicine with creativity, technology, and ethics.