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Clinical Approach to Hypoglycemia

Hypoglycemia is commonly defined as a plasma glucose concentration of less than 70 mg/dL; however, signs and symptoms may not appear until plasma glucose concentrations fall below 55 mg/dL. Since 1938, hypoglycemia has been described using the symptoms of Whipple's triad. To perform Whipple's triad, the practitioner must first diagnose hypoglycemic symptoms, then get low blood glucose, and then demonstrate instant symptom alleviation by treating the low blood glucose with glucose. Under normal circumstances, glucose serves as the brain's principal metabolic fuel source. Unlike other human tissues, the brain has a limited amount of glucose. As expected, the brain requires a continuous supply of blood glucose for proper metabolic activity. An interruption in glucose delivery has the potential to cause difficulties.

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Dr. Pratiksha Patil Profile Image

Dr. Pratiksha Patil

Consultant Diabetologist, Pratham Specialty Clinic, Mumbai

Dr. Pratiksha Patil, Consultant Diabetologist, Pratham Specialty Clinic, Mumbai

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Hypoglycemia is commonly defined as a plasma glucose concentration of less than 70 mg/dL; however, signs and symptoms may not appear until plasma glucose concentrations fall below 55 mg/dL. Since 1938, hypoglycemia has been described using the symptoms of Whipple's triad. To perform Whipple's triad, the practitioner must first diagnose hypoglycemic symptoms, then get low blood glucose, and then demonstrate instant symptom alleviation by treating the low blood glucose with glucose. Under normal circumstances, glucose serves as the brain's principal metabolic fuel source. Unlike other human tissues, the brain has a limited amount of glucose. As expected, the brain requires a continuous supply of blood glucose for proper metabolic activity. An interruption in glucose delivery has the potential to cause difficulties.