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CAR T Cells in Cancer Gene Therapy
CAR T-cell therapy is a groundbreaking approach in cancer gene therapy that harnesses a patient’s immune cells to target and destroy cancer cells. In this technique, T-cells are genetically modified to express chimeric antigen receptors (CARs) that specifically recognize cancer cells. Once reintroduced into the patient, these CAR T-cells seek out and eliminate cancer cells with high precision. This therapy has shown remarkable success in treating certain types of blood cancers, such as leukemia and lymphoma, and is being explored for solid tumors. CAR T-cell therapy offers a promising personalized treatment, with ongoing research aimed at enhancing its safety, effectiveness, and applicability to a wider range of cancers.
About the Speaker
Dr. Shibichakravarthy Kannan
Consultant Medical Genetics, Apollo Health and Lifestyle Limited, Hyderabad
Dr. Shibichakravarthy Kannan, MBBS, PhD is a Founder & CEO at Theranosis Life Sciences Pvt Ltd. He is a Physician Scientist from Chennai, India - trained in the USA . He has 15 years of clinical & translational research experience including 3 years of Industry experience in the areas - Bioinformatics, Next Generation Sequencing, Scientific communications at Novartis, Drug Discovery & Development, Clinical Genetics & tumor immunotherapy. Dr Kannan’s research focuses on Tumor Immunology & Immunotherapy. He has more than 20 research publications in high impact peer reviewed medical journals. He is Biobanking Expertise – Founded the Lymphoma Tissue Biobank at MD Anderson; replicating this model in Hyderabad & Bangalore, India and Circulating Tumor Cells – developing a platform for performing liquid biopsy of most common solid tumors such as breast, lung, prostate and colorectal cancer.
Upcoming Case Discussions
Acne: Disorders and Treatment Approaches
Acne is a common dermatological condition caused by clogged pores, excess sebum production, bacterial growth, and inflammation. It can manifest as blackheads, whiteheads, papules, pustules, or cysts, often leading to scarring if untreated. Various factors, including hormonal changes, diet, stress, and genetics, influence its severity. Treatment approaches range from topical and oral medications, such as retinoids, antibiotics, and hormonal therapy, to advanced procedures like chemical peels and laser therapy. A personalized skincare regimen, along with lifestyle modifications, plays a crucial role in managing and preventing acne.
Congenital Uterine Anomalies
Congenital uterine anomalies are structural abnormalities of the uterus resulting from improper fusion, canalization, or resorption of the Müllerian ducts during fetal development. These anomalies include septate, bicornuate, unicornuate, and didelphys uterus, among others. They can be asymptomatic or associated with infertility, recurrent pregnancy loss, preterm birth, or abnormal menstruation. Diagnosis is typically made using imaging modalities like ultrasound, MRI, or hysterosalpingography. Treatment depends on the type and severity of the anomaly, with surgical correction such as hysteroscopic septum resection often indicated in symptomatic cases. Early detection is crucial for optimizing reproductive outcomes and guiding appropriate management strategies.
Management of Postoperative Pain: Best Practices for GP’s
Effective management of postoperative pain is crucial for promoting recovery and preventing complications. General practitioners should start by assessing pain severity using appropriate scales, then tailor the treatment plan based on the patient's medical history and the type of surgery. A combination of pharmacological approaches, such as non-opioid analgesics (e.g., NSAIDs) and opioids when necessary, should be used to minimize pain while reducing the risk of addiction. Multimodal strategies, including physical therapy and non-pharmacological techniques like cold therapy or mindfulness, can further enhance pain relief. Close follow-up is essential to adjust the treatment as needed and ensure the patient's pain is well-controlled.
Diabetes and Stem Cells: What Does the Future Hold?
The future of diabetes treatment may be revolutionized by stem cell research, offering hope for a long-term cure. Scientists are developing stem cell therapies that could regenerate insulin-producing beta cells in the pancreas, potentially restoring natural insulin production in people with type 1 diabetes. Early clinical trials have shown promising results, with some patients reducing or eliminating their need for insulin injections. While challenges like immune rejection and long-term efficacy remain, continued advancements suggest stem cell therapy could significantly change diabetes management in the coming years.
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Dr. Shibichakravarthy Kannan's Talks on Assimilate
- 12th -Nov -2024, TIME : 3:00PM TO 4:00 PM
- 0
CAR T-cell therapy is a groundbreaking approach in cancer gene therapy that harnesses a patient’s immune cells to target and destroy cancer cells. In this technique, T-cells are genetically modified to express chimeric antigen receptors (CARs) that specifically recognize cancer cells. Once reintroduced into the patient, these CAR T-cells seek out and eliminate cancer cells with high precision. This therapy has shown remarkable success in treating certain types of blood cancers, such as leukemia and lymphoma, and is being explored for solid tumors. CAR T-cell therapy offers a promising personalized treatment, with ongoing research aimed at enhancing its safety, effectiveness, and applicability to a wider range of cancers.
- 12th -Nov -2024, TIME : 3:00PM TO 4:00 PM
- 0
CAR T-cell therapy is a groundbreaking approach in cancer gene therapy that harnesses a patient’s immune cells to target and destroy cancer cells. In this technique, T-cells are genetically modified to express chimeric antigen receptors (CARs) that specifically recognize cancer cells. Once reintroduced into the patient, these CAR T-cells seek out and eliminate cancer cells with high precision. This therapy has shown remarkable success in treating certain types of blood cancers, such as leukemia and lymphoma, and is being explored for solid tumors. CAR T-cell therapy offers a promising personalized treatment, with ongoing research aimed at enhancing its safety, effectiveness, and applicability to a wider range of cancers.
- 12th -Nov -2024, TIME : 3:00PM TO 4:00 PM
- 0
CAR T-cell therapy is a groundbreaking approach in cancer gene therapy that harnesses a patient’s immune cells to target and destroy cancer cells. In this technique, T-cells are genetically modified to express chimeric antigen receptors (CARs) that specifically recognize cancer cells. Once reintroduced into the patient, these CAR T-cells seek out and eliminate cancer cells with high precision. This therapy has shown remarkable success in treating certain types of blood cancers, such as leukemia and lymphoma, and is being explored for solid tumors. CAR T-cell therapy offers a promising personalized treatment, with ongoing research aimed at enhancing its safety, effectiveness, and applicability to a wider range of cancers.
- 12th -Nov -2024, TIME : 3:00PM TO 4:00 PM
- 0
CAR T-cell therapy is a groundbreaking approach in cancer gene therapy that harnesses a patient’s immune cells to target and destroy cancer cells. In this technique, T-cells are genetically modified to express chimeric antigen receptors (CARs) that specifically recognize cancer cells. Once reintroduced into the patient, these CAR T-cells seek out and eliminate cancer cells with high precision. This therapy has shown remarkable success in treating certain types of blood cancers, such as leukemia and lymphoma, and is being explored for solid tumors. CAR T-cell therapy offers a promising personalized treatment, with ongoing research aimed at enhancing its safety, effectiveness, and applicability to a wider range of cancers.