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Selection of Embryo & Transfer
Selection of embryos is a critical step in assisted reproductive technologies, aimed at identifying the healthiest and most viable embryos for transfer. Embryo selection involves analyzing the embryos' genetic makeup and morphology to increase the chances of a successful pregnancy. Preimplantation Genetic Testing (PGT) is one method used for embryo selection, allowing screening for genetic abnormalities before transfer. PGT can detect chromosomal abnormalities, single gene disorders, and structural rearrangements in embryos. Morphological assessment involves evaluating the embryo's appearance, cell number, and symmetry under a microscope. Time-lapse imaging is a technique that provides continuous monitoring of embryo development, aiding in better selection decisions. Comprehensive chromosome screening techniques, such as array Comparative Genomic Hybridization (aCGH) and Next-Generation Sequencing (NGS), can be used for PGT. Embryo grading systems, such as the Gardner or Cummins criteria, help embryologists rank embryos based on their quality. Embryos selected for transfer should ideally have a high chance of implantation and lower risk of miscarriage.
About the Speaker
Dr Charudutt Joshi
Medical Director Genes India , ART Bank
Upcoming Case Discussions
Acne: Disorders and Treatment Approaches
Acne is a common dermatological condition caused by clogged pores, excess sebum production, bacterial growth, and inflammation. It can manifest as blackheads, whiteheads, papules, pustules, or cysts, often leading to scarring if untreated. Various factors, including hormonal changes, diet, stress, and genetics, influence its severity. Treatment approaches range from topical and oral medications, such as retinoids, antibiotics, and hormonal therapy, to advanced procedures like chemical peels and laser therapy. A personalized skincare regimen, along with lifestyle modifications, plays a crucial role in managing and preventing acne.
Molecular and Genetic studies in Gynaecological Malignancies
Molecular and genetic studies in gynecological malignancies have revolutionized diagnostics, prognostics, and targeted therapies. Advances in genomic sequencing have identified key mutations in ovarian (BRCA1/2, TP53), endometrial (PTEN, MSI), and cervical cancers (HPV integration, PIK3CA). These findings aid in precision medicine, guiding individualized treatments like PARP inhibitors for BRCA-mutated ovarian cancer. Epigenetic modifications, including DNA methylation and miRNA regulation, further influence tumor progression and therapeutic response. Emerging technologies like liquid biopsies and multi-omics approaches enhance early detection and monitoring. Understanding these molecular pathways is crucial for developing novel therapies and improving survival outcomes in gynecological malignancies.
AI in Enhancing Emergency Care
AI is revolutionizing emergency care by enabling faster, more accurate decision-making. It helps triage patients efficiently, analyze medical data in real-time, and predict outcomes based on historical data, which can prioritize critical cases. AI-powered tools, like diagnostic imaging analysis and predictive algorithms, assist doctors in identifying conditions such as strokes or heart attacks earlier, improving survival rates. Additionally, AI enhances resource allocation and staff management in emergency departments, optimizing response times and reducing workload for healthcare providers.
Management of Postoperative Pain: Best Practices for GP’s
Effective management of postoperative pain is crucial for promoting recovery and preventing complications. General practitioners should start by assessing pain severity using appropriate scales, then tailor the treatment plan based on the patient's medical history and the type of surgery. A combination of pharmacological approaches, such as non-opioid analgesics (e.g., NSAIDs) and opioids when necessary, should be used to minimize pain while reducing the risk of addiction. Multimodal strategies, including physical therapy and non-pharmacological techniques like cold therapy or mindfulness, can further enhance pain relief. Close follow-up is essential to adjust the treatment as needed and ensure the patient's pain is well-controlled.
