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Approach to Resistant Hypertension
Managing resistant hypertension, a condition where blood pressure remains elevated despite treatment, requires a comprehensive approach. Resistant hypertension is typically defined as high blood pressure that remains uncontrolled despite the use of three or more different antihypertensive medications. The first step in managing resistant hypertension involves lifestyle changes, including adopting a low-sodium diet, regular exercise, weight management, and reducing alcohol intake. Healthcare providers should review current medications to ensure optimal dosing and assess for potential drug interactions or contributing factors. Identifying and treating underlying causes of secondary hypertension, such as kidney disease or hormonal disorders, is crucial. Patients are often encouraged to monitor their blood pressure at home to assess its variability and ensure accurate readings. Using combination therapies that include different classes of antihypertensive drugs can be more effective in controlling resistant hypertension.
About the Speaker

Dr. Lissy George,
Consultant Physician, IQRAA hospital, Calicut, Kerala
Dr. Lissy George is a dedicated and compassionate physician with certification in Internal Medicine and extensive experience in diagnosing and treating multiple disease states and health concerns. She has a strong background working with diverse populations, including resource-limited settings, and a special interest in Preventive medicine, Obstetric Medicine, and academic activities. Dr. George has worked as a general practitioner and a junior medical officer in various hospitals and is currently working as a consultant in General Medicine.
Upcoming Case Discussions
Conversational AI: Redefining Physician Documentation and Patient Care
Dr. Sandeep Wadhwa is a distinguished healthcare executive with extensive experience in both clinical medicine and healthcare innovation. He currently serves as the Global Chief Medical Officer at Solventum, a position he has held since October 2020, where he leads the company's medical initiatives. Additionally, Dr. Wadhwa is an Associate Clinical Professor of Medicine at the University of Colorado Health Sciences Center, a role he has held for over 26 years, contributing to both education and clinical excellence. Prior to his current position, Dr. Wadhwa was the Chief Health Officer & SVP of Market Innovation at Solera Health, where he focused on addressing chronic disease and improving health outcomes through innovative community and digital health solutions. His previous leadership roles include SVP of Product Management and CMO at Noridian Healthcare Solutions and CMO & Business Unit Vice President at 3M Health Information Systems. Dr. Wadhwa earned his MD from Joan & Sanford I. Weill Medical College of Cornell University and an MBA from The Wharton School, blending medical expertise with business acumen to drive impactful healthcare strategies.
Alpha Lipoic Acid: Pharmacokinetics & Applications
Alpha-lipoic acid (ALA) is a naturally occurring antioxidant involved in mitochondrial energy metabolism. It is rapidly absorbed in the gastrointestinal tract and distributed throughout the body, with high concentrations in the liver and kidneys. ALA is both water- and fat-soluble, allowing it to neutralize free radicals in various environments. It undergoes extensive hepatic metabolism and is excreted primarily via the urine. ALA has therapeutic applications in managing conditions like diabetes, neurodegenerative diseases, and as a supplement for its antioxidant benefits.
Hyperlipidemia: From Diagnosis to Treatment
Hyperlipidemia is a condition characterized by elevated levels of lipids, such as cholesterol and triglycerides, in the blood, which can increase the risk of cardiovascular diseases. Diagnosis typically involves blood tests measuring lipid profiles, while treatment focuses on lifestyle changes, such as diet and exercise, alongside medications like statins to manage cholesterol levels and reduce cardiovascular risk. Regular monitoring is essential for effective management and prevention of complications.
Acne: Disorders and Treatment Approaches
Acne is a common dermatological condition caused by clogged pores, excess sebum production, bacterial growth, and inflammation. It can manifest as blackheads, whiteheads, papules, pustules, or cysts, often leading to scarring if untreated. Various factors, including hormonal changes, diet, stress, and genetics, influence its severity. Treatment approaches range from topical and oral medications, such as retinoids, antibiotics, and hormonal therapy, to advanced procedures like chemical peels and laser therapy. A personalized skincare regimen, along with lifestyle modifications, plays a crucial role in managing and preventing acne.
Safer Alternatives in Pain Management
Safer alternatives in pain management focus on reducing the reliance on opioids and minimizing the risk of addiction or side effects. Non-opioid medications such as acetaminophen, NSAIDs, and anticonvulsants are increasingly used for managing both acute and chronic pain. Additionally, physical therapy, acupuncture, and cognitive-behavioral therapy are non-pharmacological approaches that effectively address pain without the risks associated with traditional painkillers. For certain cases, interventional procedures like nerve blocks or spinal cord stimulation offer targeted relief while minimizing systemic side effects. These alternatives aim to provide effective pain management while enhancing patient safety and quality of life.