3.48 CME

إدارة متلازمة التمثيل الغذائي عند الأطفال

المتحدث: Dr. Rashi Agrawal

Consultant Endocrinologist, Kokilaben Dhirubhai Ambani Hospital, Navi Mumbai

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وصف

The management of metabolic syndrome in children is crucial due to its association with long-term risks like cardiovascular disease and type 2 diabetes. Metabolic syndrome is characterized by a cluster of conditions, including obesity, insulin resistance, dyslipidemia, and hypertension. Early intervention is key to preventing these complications.

The primary treatment approach involves lifestyle modification. Encouraging a balanced diet rich in fruits, vegetables, and whole grains, while reducing intake of sugary and processed foods, can help improve weight management and metabolic health. Regular physical activity, such as 60 minutes of moderate exercise daily, is also essential to enhance insulin sensitivity and promote cardiovascular fitness.

ملخص

  • Metabolic syndrome is a cluster of conditions, including abdominal obesity, insulin resistance, hypertension, and dyslipidemia, that increase the risk of heart disease, stroke, and type 2 diabetes. There isn't a fixed definition for pediatric metabolic syndrome, with over 40 definitions suggested in the literature. Despite the lack of standard guidelines, identifying these symptoms in children is important, as they may present with one or more of these risk factors.
  • The prevalence of metabolic syndrome in children has increased, particularly in the last decade, due to increased exposure to social media, affordability of junk food, and sedentary lifestyles. Studies indicate that approximately 5 to 10% of children meet the criteria for metabolic syndrome. A study in the British Medical Journal in 2022 showed that about 5.2% of adolescents in India suffer from pediatric metabolic syndrome according to the International Diabetes Federation (IDF) criteria.
  • Metabolic syndrome is associated with risks such as type 2 diabetes, cardiovascular disease, metabolic-associated fatty liver disease, polycystic ovarian disease, and certain cancers. News articles indicate an increase in heart attacks among young children, along with a rising prevalence of type 2 diabetes. Risk factors for metabolic syndrome include non-modifiable (genetic) and modifiable (environmental) factors.
  • Environmental factors, such as sedentary lifestyles, unhealthy diets, and socioeconomic status, contribute to the majority of cases. A meta-analysis published in 2019 showed that a low socioeconomic gradient is associated with an increased risk of metabolic syndrome. A recent ICMR study highlights the impact of ultra-processed food consumption on diabetes rates in India.
  • The International Diabetes Federation (IDF) criteria are used in several studies to define pediatric metabolic syndrome. The National Education Program ATP III (Adult Treatment Panel III) criteria is an other criteria for diagnosing metabolic syndrome, focusing on waist circumference, triglyceride levels, HDL, blood pressure, and fasting blood glucose. Management of metabolic syndrome starts with primary prevention, focusing on early identification and intervention, promoting healthy lifestyle changes, and regular monitoring of growth and metabolic parameters.
  • Dietary recommendations involve increasing vegetable and fruit consumption, as well as protein, while decreasing carbohydrate and ultra processed food consumption. Physical activity is non-negotiable, with recommendations for a minimum of 60 minutes of vigorous physical activity daily, while limiting screen time. Adequate sleep hygiene is crucial, with 8 to 10 hours of uninterrupted sleep at night.
  • Behavioral interventions, including counseling to promote healthy eating and physical activity, and family involvement are essential. Tracking progress involves setting SMART goals, utilizing technology for monitoring, and engaging in group activities for better results. Pharmacological treatments include metformin, GLP-1 analogs, SGLT2 inhibitors, and long-acting insulins, directed towards components of the metabolic syndrome.
  • Surgical interventions, such as bariatric surgery, may be considered in specific circumstances. Psychological support and the availability of support groups are important for children dealing with these conditions. Government initiatives promoting health and wellness contribute to prevention and management. A multi-faceted approach is necessary to build a healthy society.

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