3.02 CME

Endoscopic Diagnosis and Treatment of Peptic Ulcer

المتحدث: Dr. Sadguna rao Amara

Consultant Gastroenterologist at Veda Gastro and Liver care Hospital, Kamareddy, Telangana

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وصف

Endoscopy plays a pivotal role in diagnosing and treating peptic ulcers, which are sores that develop on the stomach lining, duodenum, or esophagus. Through endoscopic examination, healthcare providers can visually inspect the gastrointestinal tract, accurately identifying ulcer location, size, and severity. Endoscopy is particularly beneficial in detecting complications such as bleeding or perforation, which may require immediate intervention.During the procedure, biopsies can be taken to rule out malignancies or detect Helicobacter pylori infection, a common cause of peptic ulcers. Endoscopic treatment options for peptic ulcers include injecting medications to control bleeding, applying thermal therapy to cauterize the ulcer, or placing clips or bands to close vessels. This minimally invasive approach provides rapid relief, reduces the need for surgery, and accelerates recovery. Endoscopic intervention is essential in both diagnosing and managing peptic ulcers, as it enables targeted treatment, reducing risks and improving patient outcomes.

ملخص

  • Peptic ulcer disease is defined by breaks in the GI tract lining, classified by size, depth, or histological evidence. H. pylori infection and NSAID use are major etiological factors. Bleeding is the most frequent complication, followed by perforation and gastric outlet obstruction. Recent guidelines update H. pylori treatment, including both PPI and non-PPI based therapies.
  • Initial assessment of GI bleeding patients requires stabilizing airway, breathing, and circulation, alongside a detailed medical history. Risk scores, like the Glasgow Blatchford score, aid in initial assessment, although clinical judgment is paramount. Resuscitation is key, considering IV fluids or blood products based on hemodynamic status.
  • Endoscopy timing is crucial; emergent endoscopy is reserved for patients with persistent instability or significant bleeding. Before endoscopy, prokinetics and prophylactic antibiotics should be considered. Nasogastric tubes are debated, but can provide diagnostic insights. Anesthetist administered sedation is preferred, with potential airway protection during endoscopy.
  • During endoscopy, avoid premature clot removal and ensure thorough examination for multiple lesions. Clots can be manipulated through patient repositioning or specialized tools. Forrest classification is vital for risk assessment and treatment planning after identifying the bleeding source. Dual therapy, combining injection and thermal or mechanical methods, is generally favored.
  • Endoscopic hemostasis involves injection, thermal, mechanical, and topical therapies. Adrenaline injection provides temporary tamponade and vasoconstriction, but is not effective alone. Thermal devices such as gold probes and coag graspers induce coagulation and edema. Hemoclips offer mechanical closure, with varied properties impacting their suitability for different situations.
  • Overscope clips act as rescue treatments for complex lesions. Topical agents like Hemospray promote hemostasis by sealing vessels and activating coagulation. Endoscopic Doppler probes assist in assessing the completeness of hemostasis. Intervention radiology and surgical therapies are options for cases that fail endoscopy.
  • Peptic ulcer perforation may be managed with over-the-scope clips in certain situations. Gastric outlet obstruction due to peptic ulcers is primarily treated with balloon dilation. Successful management of peptic ulcer bleeds involves effective resuscitation, thorough lesion assessment, and appropriate post-endoscopic care.

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