Clinician's Approach to Septic Shock

The prognosis of sepsis syndromes varies and spans a clinical spectrum. The most serious consequence of sepsis, septic shock, has a high death rate. An inciting substance triggers the activation of both the pro-inflammatory and anti-inflammatory immune systems, leading to septic shock. This takes place in tandem with the activation of neutrophils, monocytes, and macrophages, which engage with the endothelium via pathogen recognition receptors and cause further cytokine, protease, kinin, reactive oxygen species, and nitric oxide involvement. The endothelium is the main location of this reaction, and in addition to microvascular damage, it also triggers the complement and coagulation cascades, which worsen the vascular damage and cause capillary leakage. The clinical signs and symptoms of sepsis and the progression from sepsis are caused by this series of events.