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Innovations in Cancer Therapy

वक्ता: Dr. G. V. Nagarjuna Reddy

Head & Neck Oncosurgeon, MAA ENT Hospitals, Hyderabad.

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विवरण

Innovations in Cancer Therapy have revolutionized treatment by offering more precise, effective, and less invasive options. Immunotherapy, including checkpoint inhibitors and CAR-T cell therapy, enhances the body's natural defense against cancer. Targeted therapies focus on specific genetic mutations, minimizing side effects compared to traditional treatments. Personalized medicine tailors treatments based on a patient’s genetic profile, improving outcomes. Advancements in radiation therapy now allow for higher precision with minimal damage to healthy tissues. Additionally, nanotechnology and AI-driven drug discovery are accelerating the development of novel cancer treatments, paving the way for more efficient and patient-centric care.

सारांश

  • Cancer incidence is on the rise globally, especially in developing countries like India, necessitating increased awareness and advancements in treatment. The theme for World Cancer Day (2025-2027) is "United by Uni", emphasizing collaborative efforts in cancer care.
  • Cutting-edge therapies in oncology include immunotherapy, particularly CAR T-cell therapy, where a patient's T-cells are modified to target cancer cells. While promising, CAR T-cell therapy currently has limited applications and is available in specialized centers. Immune checkpoint inhibitors are another advancement, blocking checkpoints in cancer cells to halt division and promote cell death.
  • Precision medicine and targeted therapies focus on personalized treatment based on an individual's genetic makeup and disease characteristics. Personalized cancer vaccines, though still in clinical trials, aim to target specific genomic defects in cancer cells. Artificial intelligence (AI) is being utilized in oncology to aid in diagnosis, treatment planning, and predicting cancer incidence.
  • Innovations in radiation therapy include intensity-modulated radiation therapy (IMRT), volumetric arc therapy (V-MAT), and stereotactic body radiation therapy (SBRT), which offer more precise and targeted radiation delivery. Particle therapy, using proton beams or carbon ions, provides better depth of penetration and less surrounding radiation. Interventional radiology techniques like transarterial chemoembolization (TACE) and thermal ablation are also advancing.
  • Early detection is critical for improving cancer outcomes, and advancements include liquid biopsies, which use blood samples to identify circulating tumor DNA. Multiomics, which integrates genomics, transcriptomics, proteomics, and metabolomics, is also playing a key role in early cancer detection and understanding.
  • Empowering patients through education and awareness is essential, particularly in countries like India where patient awareness may be limited. Cancer survivorship, which focuses on improving quality of life after treatment, is an increasingly important aspect of cancer care. This involves addressing physical, psychological, and social challenges faced by cancer survivors.

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